The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway

F-box and WD repeat domain-containing 5 (FBXW5), with WD40 repeats, can bind to the PPxY sequence of the large tumor suppressor kinases 1/2 (LATS1/2) kinase domain, resulting in ubiquitination. Ubiquitination and the subsequent degradation of LATS1/2 abrogate the Hippo pathway and worsen gastric can...

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Veröffentlicht in:	Cell death discovery 2022-02, Vol.8 (1), p.79-79, Article 79
Hauptverfasser:	Yao, Yangyang, Liu, Zhen, Huang, Shanshan, Huang, Chunye, Cao, Yuan, Li, Li, Guo, Hui, Liu, Fenfen, Huang, Shipeng, Liao, Quan, He, Xin, Chen, Jun, Li, Junhe, Xiang, Xiaojun, Xiong, Jianping, Deng, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1504 631/67/1857 Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell proliferation Chemoresistance Degradation Drug resistance Gastric cancer Immunohistochemistry Immunoprecipitation Life Sciences Lymph nodes Metastases Metastasis Molecular modelling Signal transduction Stem Cells Tumor suppressor genes Tumors Ubiquitin Ubiquitin-protein ligase Ubiquitination Xenografts Yes-associated protein
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Zusammenfassung:	F-box and WD repeat domain-containing 5 (FBXW5), with WD40 repeats, can bind to the PPxY sequence of the large tumor suppressor kinases 1/2 (LATS1/2) kinase domain, resulting in ubiquitination. Ubiquitination and the subsequent degradation of LATS1/2 abrogate the Hippo pathway and worsen gastric cancer (GC). However, the effects and molecular mechanisms of FBXW5 in GC remain unexplored. To elucidate the clinical significance of FBXW5, immunohistochemistry was conducted to reveal the positive correlation between FBXW5 expression and lymph node metastasis ( p
ISSN:	2058-7716 2058-7716
DOI:	10.1038/s41420-022-00868-y