Application of quantitative systems pharmacology to guide the optimal dosing of COVID‐19 vaccines

Application of quantitative systems pharmacology to guide the optimal dosing of COVID‐19 vaccines

Optimal use and distribution of coronavirus disease 2019 (COVID‐19) vaccines involves adjustments of dosing. Due to the rapidly evolving pandemic, such adjustments often need to be introduced before full efficacy data are available. As demonstrated in other areas of drug development, quantitative sy...

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Veröffentlicht in:CPT: Pharmacometrics & Systems Pharmacology 2021-10, Vol.10 (10), p.1130-1133
Hauptverfasser: Giorgi, Mario, Desikan, Rajat, Graaf, Piet H., Kierzek, Andrzej M.
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
B cells
Biology
Clinical trials
Coronaviruses
COVID-19 vaccines
Drug development
Drug dosages
Epidemics
Health aspects
Immunology
Optimization
Ordinary differential equations
Pandemics
Pharmacokinetics
Pharmacology
Regulatory approval
RNA
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Vaccination
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Zusammenfassung:Optimal use and distribution of coronavirus disease 2019 (COVID‐19) vaccines involves adjustments of dosing. Due to the rapidly evolving pandemic, such adjustments often need to be introduced before full efficacy data are available. As demonstrated in other areas of drug development, quantitative systems pharmacology (QSP) is well placed to guide such extrapolation in a rational and timely manner. Here, we propose for the first time how QSP can be applied in the context of COVID‐19 vaccine development.
ISSN:2163-8306
2163-8306
DOI:10.1002/psp4.12700