Anti-inflammatory lignans from the fruits of Acanthopanax sessiliflorus

A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY,...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2012-12, Vol.18 (1), p.41-49
Hauptverfasser:	Lee, Dae-Young, Seo, Kyeong-Hwa, Jeong, Rak-Hun, Lee, Sang-Min, Kim, Geum-Soog, Noh, Hyung-Jun, Kim, Seung-Yu, Kim, Gye-Won, Kim, Ji-Young, Baek, Nam-In
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthopanax sessiliflorus acanthosessilin A Animals Anti-Inflammatory Agents - pharmacology Carbon Cell Line Cell Survival - drug effects Eleutherococcus - chemistry Fruit - chemistry Hydrocarbons Inhibitory Concentration 50 lignan Lignans - pharmacology Lipopolysaccharides Macrophages - drug effects Macrophages - metabolism Magnetic fields Magnetic Resonance Spectroscopy Mice Nitric oxide Nitric Oxide - metabolism Phytochemicals Plant Extracts - pharmacology Protons Spectrum analysis
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Beschreibung
Zusammenfassung:	A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules18010041