Role of PAD enzymes on histone citrullination in cancer

Role of PAD enzymes on histone citrullination in cancer

Citrullination process is a natural pathway which happened at the time of cell dying, but during removal of these products, PAD enzymes may release causing stimuli to the immune system. This can start a consequence of processes and enhancement of cancer disease. In this review, we will focus on this...

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Veröffentlicht in:Medical Journal of Babylon 2022-10, Vol.19 (4), p.514-517
Hauptverfasser: Abdulrahman, Noor, Ali, Shatha
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Apoptosis
Cancer
citrullination
Citrulline
Diagnosis
DNA binding proteins
Health aspects
histone
Histones
pad-4
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Zusammenfassung:Citrullination process is a natural pathway which happened at the time of cell dying, but during removal of these products, PAD enzymes may release causing stimuli to the immune system. This can start a consequence of processes and enhancement of cancer disease. In this review, we will focus on this marker and significance of its application for early detection of cancer and for follow-up disease, and the latest approved medications act on this line.
ISSN:1812-156X
2312-6760
DOI:10.4103/MJBL.MJBL_148_22