The role of hemoglobin in nitric oxide transport in vascular system

Nitric oxide (NO) plays a pivotal role in vascular homeostasis and its functions practice in a dose-dependent manner in which too high and too low NO concentration may both induce the development of cardiovascular diseases, which indicates the balance between NO formation and scavenging is critical....

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Veröffentlicht in:Medicine in novel technology and devices 2020-03, Vol.5, p.100034, Article 100034
Hauptverfasser: Su, Haoran, Liu, Xiao, Du, Jing, Deng, Xiaoyan, Fan, Yubo
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Sprache:eng
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Zusammenfassung:Nitric oxide (NO) plays a pivotal role in vascular homeostasis and its functions practice in a dose-dependent manner in which too high and too low NO concentration may both induce the development of cardiovascular diseases, which indicates the balance between NO formation and scavenging is critical. Evidence presented over the last two decades has indicated hemoglobin (Hb) can affect NO dynamic equilibrium. The role of Hb was once thought to play in NO signaling as inhibiting NO transport, but now several mechanisms have found that Hb may preserve and even regulate NO activity. Despite the tremendous amount of work devoted to this field, major questions concerning precise mechanisms of NO activity preservation as well as if and how Hb creates NO activity remain unanswered. In this review, we discuss the role of hemoglobin in NO formation, transport and consumption. We also discuss how these mechanisms of the imbalance between NO and hemoglobin induce related diseases, which may serve as the basis for novel therapeutics. •Compartmentalization of Hb in the red blood cell and blood vessels can affect the transport of NO containing consumption and formation.•Nitrite can mediate NO activity export from red blood cells.•The relation of Hb and NO help to identify novel therapeutic strategies in vascular system.
ISSN:2590-0935
2590-0935
DOI:10.1016/j.medntd.2020.100034