Cerebral White Matter Hyperintensities, Kidney Function Decline, and Recurrent Stroke After Intensive Blood Pressure Lowering: Results From the Secondary Prevention of Small Subcortical Strokes ( SPS 3) Trial

Cerebral White Matter Hyperintensities, Kidney Function Decline, and Recurrent Stroke After Intensive Blood Pressure Lowering: Results From the Secondary Prevention of Small Subcortical Strokes ( SPS 3) Trial

Background We aimed to determine whether cerebral white matter hyperintensities ( WMHs ) can distinguish stroke survivors susceptible to rapid kidney function decline from intensive blood pressure ( BP ) lowering. Methods and Results The SPS3 (Secondary Prevention of Small Subcortical Strokes) trial...

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Veröffentlicht in:Journal of the American Heart Association 2019-02, Vol.8 (3), p.e010091
Hauptverfasser: Ikeme, Jesse C, Pergola, Pablo E, Scherzer, Rebecca, Shlipak, Michael G, Catanese, Luciana, McClure, Leslie A, Benavente, Oscar R, Peralta, Carmen A
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - adverse effects
blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
creatinine
Creatinine - blood
Dose-Response Relationship, Drug
estimated glomerular filtration rate
Female
Follow-Up Studies
Glomerular Filtration Rate - physiology
Humans
Hypertension - complications
Hypertension - drug therapy
Incidence
kidney
lacunar stroke
Magnetic Resonance Imaging
Male
Middle Aged
Original Research
Prospective Studies
Recurrence
Renal Insufficiency - epidemiology
Renal Insufficiency - etiology
Renal Insufficiency - prevention & control
Secondary Prevention - methods
secondary prevention of small subcortical strokes
Stroke, Lacunar - epidemiology
Stroke, Lacunar - etiology
Stroke, Lacunar - prevention & control
United States - epidemiology
White Matter - pathology
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Zusammenfassung:Background We aimed to determine whether cerebral white matter hyperintensities ( WMHs ) can distinguish stroke survivors susceptible to rapid kidney function decline from intensive blood pressure ( BP ) lowering. Methods and Results The SPS3 (Secondary Prevention of Small Subcortical Strokes) trial randomized participants with recent lacunar stroke to systolic BP targets of 130 to 149 and
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.118.010091