Progress in Catalytic Asymmetric Reactions with 7-Azaindoline as the Directing Group

α-Substituted-7-azaindoline amides and α,β-unsaturated 7-azaindoline amides have emerged as new versatile synthons for various metal-catalyzed and organic-catalyzed asymmetric reactions, which have attracted much attention from chemists. In this review, the progress of research on 7-azaindoline amid...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2023-12, Vol.28 (23), p.7898
Hauptverfasser: Zhang, Yan-Ping, You, Yong, Yin, Jun-Qing, Wang, Zhen-Hua, Zhao, Jian-Qiang, Yuan, Wei-Cheng
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Sprache:eng
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Zusammenfassung:α-Substituted-7-azaindoline amides and α,β-unsaturated 7-azaindoline amides have emerged as new versatile synthons for various metal-catalyzed and organic-catalyzed asymmetric reactions, which have attracted much attention from chemists. In this review, the progress of research on 7-azaindoline amides in the asymmetric aldol reaction, the Mannich reaction, the conjugate addition, the 1,3-dipole cycloaddition, the Michael/aldol cascade reaction, aminomethylation and the Michael addition-initiated ring-closure reaction is discussed. The α-substituted-7-azaindoline amides, as nucleophiles, are classified according to the type of α-substituted group, whereas the α,β-unsaturated 7-azaindoline amides, as electrophiles, are classified according to the type of reaction.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28237898