Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada

Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada

Three new inositol angelate compounds ( ) and two new tirucallane-type alkaloids ( and ) were isolated from the , and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds and exhibited signifi...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2020-03, Vol.25 (5), p.1222
Hauptverfasser: Yang, Sheng-Xiang, Song, Cheng-Gang, Kuang, Yi, Liu, Bing, Zhang, Yan-Xin, Zhang, Ming-Zhe, Zhang, Chun-Ying, Ding, Gang, Qin, Jian-Chun
Format: Artikel
Sprache:eng
Schlagworte:
Aglaia - chemistry
Alkaloids
Alkaloids - chemistry
Alkaloids - pharmacology
amoora dasyclada
Artemia
Cancer
Carbon
Cell Proliferation - drug effects
Cytotoxicity
Cytotoxicity testing
Hep G2 Cells
Humans
Inositol
Inositol - analogs & derivatives
Inositol - chemistry
Inositol - pharmacology
inositol angelate
Larvae
Neoplasms - drug therapy
NMR
Nuclear magnetic resonance
tirucallane alkaloid
Toxicity testing
Triterpenes - chemistry
Triterpenes - pharmacology
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Zusammenfassung:Three new inositol angelate compounds ( ) and two new tirucallane-type alkaloids ( and ) were isolated from the , and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds and exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC value at 8.4 and 13.2 μM. In addition, compounds and also showed remarkable growth inhibitory activity to larvae.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25051222