A prospective study of hepatic safety of statins used in very elderly patients

Statins play an important role in the care of patients with cardiovascular disease and have a good safety record in clinical practice. Hepatotoxicity is a barrier that limits the ability of primary care physicians to prescribe statins for patients with elevated liver transaminase values and/or under...

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Veröffentlicht in:	BMC geriatrics 2019-12, Vol.19 (1), p.352-7, Article 352
Hauptverfasser:	Guo, Meizi, Zhao, Junli, Zhai, Yingjiu, Zang, Panpan, Lv, Qing, Shang, Dongya
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged, 80 and over Alcohol abuse Alcoholism Analysis Antilipemic agents Arteriosclerosis Atherosclerosis Atorvastatin Cardiac patients Cardiovascular disease Cardiovascular diseases Care and treatment Carotid arteries Chronic diseases Chronic illnesses Chronic infection Confidence intervals Coronary artery disease Coronary Disease - blood Coronary Disease - drug therapy Coronary heart disease Diabetes Drinking (Alcoholic beverages) Drug abuse Drug dosages Elderly Elderly patients Enzymes Fatty liver Female Fluvastatin Geriatrics Health risk assessment Health sciences Heart diseases Heart failure Hepatitis Hepatitis B Hepatotoxicity Hospitals Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Infections Liver Liver - drug effects Liver - enzymology Liver diseases Liver failure Low density lipoprotein Low density lipoproteins Male Medical practice Medical research Multivariate analysis Older people Patients Physicians Pravastatin Primary care Prospective Studies Regression analysis Rosuvastatin Safety and security measures Safety regulations Simvastatin Software Statins Transaminase Transaminases - blood Very elderly
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Beschreibung
Zusammenfassung:	Statins play an important role in the care of patients with cardiovascular disease and have a good safety record in clinical practice. Hepatotoxicity is a barrier that limits the ability of primary care physicians to prescribe statins for patients with elevated liver transaminase values and/or underlying liver disease. However, limited population-based data are available on the use of statin therapy and on the hepatotoxicity of statins in very elderly patients. This prospective study evaluated the liver enzyme elevation during statin therapy in very elderly patients (≥80 years old). Patients with hypercholesterolemia (LDL-C levels ≥3.4 and
ISSN:	1471-2318 1471-2318
DOI:	10.1186/s12877-019-1361-2