Regulation of antimicrobial activity and xenocoumacins biosynthesis by pH in Xenorhabdus nematophila

Regulation of antimicrobial activity and xenocoumacins biosynthesis by pH in Xenorhabdus nematophila

Xenocoumacin 1 (Xcn1) and Xenocoumacin 2 (Xcn2) are the main antimicrobial compounds produced by Xenorhabdus nematophila. Culture conditions, including pH, had remarkably distinct effects on the antimicrobial activity of X. nematophila. However, the regulatory mechanism of pH on the antimicrobial ac...

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Veröffentlicht in:Microbial cell factories 2017-11, Vol.16 (1), p.203-203, Article 203
Hauptverfasser: Guo, Shuqi, Zhang, Shujing, Fang, Xiangling, Liu, Qi, Gao, Jiangtao, Bilal, Muhammad, Wang, Yonghong, Zhang, Xing
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotic production
Antibiotics
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Bacteria
Biological control
Biological pest control
Biosynthesis
Enzymes
Fermentation
Genes
Genetic engineering
Genomes
Gram-negative bacteria
Metabolites
Natural products
Pesticides
pH effects
Physiological aspects
Regulation
Regulatory mechanisms (biology)
Stress response
Xenorhabdus nematophila
Xenorhabdus nematophila YL001
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Zusammenfassung:Xenocoumacin 1 (Xcn1) and Xenocoumacin 2 (Xcn2) are the main antimicrobial compounds produced by Xenorhabdus nematophila. Culture conditions, including pH, had remarkably distinct effects on the antimicrobial activity of X. nematophila. However, the regulatory mechanism of pH on the antimicrobial activity and antibiotic production of this bacterium is still lacking. With the increase of initial pH, the antimicrobial activity of X. nematophila YL001 was improved. The levels of Xcn1 and nematophin at pH 8.5 were significantly (P 
ISSN:1475-2859
1475-2859
DOI:10.1186/s12934-017-0813-7