Fly model sheds light on brain disease

Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.

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Bibliographische Detailangaben
Veröffentlicht in:	eLife 2019-12, Vol.8
Hauptverfasser:	Berryer, Martin H, Kosmaczewski, Sara G, Barrett, Lindy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Diseases cysteine-string protein Death Dementia Diptera Disease Heat shock proteins Humans Insight lysosome Mutation Neurodegeneration neuronal ceroid lipofuscinosis Neuronal Ceroid-Lipofuscinoses Neurons Neurophysiology Neuroscience Pathology Proteins Seizures (Medicine)
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Beschreibung
Zusammenfassung:	Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.
ISSN:	2050-084X 2050-084X
DOI:	10.7554/eLife.53233