Phenolic Content, Antioxidant Activity, and Tyrosinase Inhibitor Potential for both Skin and Physical Health: Test of Extract, Skin Content and Content of Garcinia Cowa Fruit

Skin aging leads to reduced structural integrity and reduced skin function. Medicinal plant extracts that have antioxidant properties and are able to inhibit tyrosinase have become a trend in various uses for anti-aging. One of the commonly used plants in traditional medicine that grows in many Asian countries is garcinia cowa. Currently, no one has studied the fruit from two different aspects, namely for the skin and to help in physical improvement. The purpose of this study is to test the phenolic content, antioxidants, and tyrosinase inhibition activity of the extract from the skin and pulp of garcinia cowaas well as its effectiveness on the physical ability and function of the skin. The stages carried out start from the collection of garcina cowafruits, the determination of total phenolic levels, the determination of antioxidant activity, and the determination of tyrosinase inhibition activity. The total phenolic content was deter-mined by the folin-ciocalteu method. The phenolic content of garcinia cowafruit peel extract is 17,789 mg of gallic acid equivalent extract (GAE)/g, while the meat extract is 12,078 mg GAE/g extract. Furthermore, the flesh of garcinia cowashowed weak antioxidant activity with an IC50 value of 490.2 μg/mL, but the fruit peel extract showed moderate antioxidant activity at 243.3 μg/mL. The skin of garcinia cowafruit shows tyrosinase inhibition activity in vitro, which is more significant than the pulp. Garcinia cowapeel and pulp extracts both contain phenolic compounds and show the antioxidant activity, but it was found that the fruit peel extract has a higher content. This means that with its antioxidant content, it can ward off free radicals, prevent cell damage, and reduce the risk of chronic diseases. The combination of phenolic content, antioxidant activity, and tyrosinase inhibitor potential provides significant benefits for skin health and overall physical health. El envejecimiento de la piel conduce a una reducción de la integridad estructural y la disminución de la función de la piel. Los extractos de plantas medicinales que tienen propiedades antioxidantes y son capaces de inhibir la tirosinasa se han convertido en una tendencia en diversos usos para el antienvejecimiento. Una de las plantas más utilizadas en la medicina tradicional que crece en muchos países asiáticos es la garcinia cowa. Actualmente, nadie ha estudiado la fruta desde dos aspectos diferentes, a saber, para la piel y para ayudar en la mejora física. E