Efecto de la exposición prenatal al paraquat (gramoxone® n.f.) en ratas biou: wistar. Estudio preliminar

The aim of the research was to determine the effect of prenatal exposure to the paraquat (PQ) on craniofacial and body conformation in BIOU rats: Wistar. Methodology: fifty pregnant rats were distributed in five groups: PQ1 and PQ2, respectively received 2 and 3 mg / kg of PQ via subcutaneous (s.c);...

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Veröffentlicht in:GICOS: Revista del Grupo de Investigaciones en Comunidad y Salud 2021, Vol.6 (4), p.132-150
Hauptverfasser: Quiñónez, Belkis, León, Wanda, Álvarez, Oriana, Arismendi, Johana, Rincón García, Ángel
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Sprache:spa
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Zusammenfassung:The aim of the research was to determine the effect of prenatal exposure to the paraquat (PQ) on craniofacial and body conformation in BIOU rats: Wistar. Methodology: fifty pregnant rats were distributed in five groups: PQ1 and PQ2, respectively received 2 and 3 mg / kg of PQ via subcutaneous (s.c); vitamin A (positive control): treated with 100,000 IU of vitamin A intragastric route (i.g) and control groups (distilled water, s.c route and i.g route). The treatments were administered from 6th to the 15th day of gestation. On days 6, 14 and 21 the maternal weight was compared. On the last day, a laparotomy was performed and the number of implantations, reabsorptions, live and dead fetuses, fetal weight and height, and the presence of craniofacial and body alterations were determined. Results: there was no significant difference in maternal weight gain between the groups. In the PQ 2mg / Kg and vitamin A groups, the highest number of dead fetuses and reabsorptions were respectively registered. The fetuses weight and height in the vitamin A group was lower (p
ISSN:2610-797X