Comprometimento cognitivo e qualidade de vida de pacientes submetidos ao transplante de células-tronco hematopoiéticas

Objective: To assess and correlate overall quality of life and the cognitive function of adult patients with hematologic cancer subjected to autologous and allogeneic hematopoietic stem cell transplantations up to three years after treatment. Materials and method: A longitudinal, observational, and analytical study was conducted with 55 patients in a reference hospital in Latin America, from September 2013 to February 2019, with the Quality of Life Questionnaire-Core 30, analyzed with the Spearman’s correlation coefficient and Generalized Linear Mixed Model tests. Results: Overall quality of life in autologous and allogeneic transplantations presented a decline in the pancytopenia phase (59.3 and 55.3, respectively). There was impairment of the cognitive function in the autologous group in post-transplantation after two years (61.90) and, in the allogeneic group (74), in pancytopenia. In the autologous group, a positive (0.76) and significant (p < 0.04) correlation is observed between the cognitive domain and quality of life in post-transplantation after two years. In the allogeneic group, there was a positive (0.55) and significant (p < 0.00) correlation from 180 days after transplantation. Conclusions: Quality of life and the cognitive function present impairment and there is a correlation after the hematopoietic stem cell transplantation for both groups: autologous and allogeneic. Objetivo: avaliar e correlacionar a qualidade de vida geral e a função cognitiva de pacientes adultos com câncer hematológico submetidos ao transplante de células-tronco hematopoéticas autólogo e alogênico até três anos após o tratamento. Materiais e método: estudo longitudinal, observacional e analítico com 55 pacientes, num hospital de referência na América Latina, de setembro de 2013 a fevereiro de 2019, com o instrumento Quality of Life Questionnarie-Core 30, analisado com os testes coeficiente de correlação de Spearman e o Generalized Linear Mixed Model. Resultados: a qualidade de vida geral no transplante autólogo e alogênico apresentaram declínio na fase de pancitopenia (59,3 e 55,3, respectivamente). Houve comprometimento da função cognitiva no grupo autólogo no pós-transplante dois anos (61,90) e no grupo alogênico (74), na pancitopenia. Observa-se, no grupo autólogo, correlação positiva (0,76) e significativa (p < 0,04) entre o domínio cognitivo e a qualidade de vida no pós-transplante dois anos. No grupo alogênico, houve correlação positiva (0,55) e significativa (p