Dying to live. Cell death as a regulatory process

Usually, the organization of living systems is explained by appealing to an intrinsic purpose that is based on the biological survival. However, paradigmatically, it is inevitable to observe that the final destiny of all living organisms is death. In this work, we defend that, from an organizational...

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Veröffentlicht in:Theoria (Madrid, Spain) Spain), 2020, Vol.35 (2), p.197-215
Hauptverfasser: Saborido Alejandro, Cristian, Favre, Cristián, Campero, María Belén
Format: Artikel
Sprache:eng ; spa
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Zusammenfassung:Usually, the organization of living systems is explained by appealing to an intrinsic purpose that is based on the biological survival. However, paradigmatically, it is inevitable to observe that the final destiny of all living organisms is death. In this work, we defend that, from an organizational approach, there is a form of death—Regulatory Cell Death—that, far from being a mere "absence of life", is a process of biological regulation and a feature of self-maintenance in multicellular organisms. Habitualmente, la organización de los sistemas vivientes se explica apelando a una finalidad intrínseca que se fundamenta en la supervivencia biológica. Pero, paradigmáticamente, es inevitable observar que el destino final de todos los organismos vivos es la muerte. En este trabajo defenderemos que, desde un enfoque organizacional, hay una forma de muerte—la Muerte Celular Regulada—que, lejos de ser mera "ausencia de vida", es un proceso de regulación biológica característico del auto-mantenimiento biológico de los multicelulares.
ISSN:0495-4548
2171-679X
DOI:10.1387/theoria.20514