Historia reproductiva y fecundidad en pacientes con proteinopatías del Sistema Nervioso

It is known that several proteinopathies of the nervous system are associated with significant changes in reproductive history and fertility.Objective: To show the behavior of reproductive history and fertility in patients with proteinopathies of the nervous system.Material and Methods: A literature review was carried out from January, 2018 to December, 2018. Search was carried out in databases like PubMed, EBSCO, Google Scholar and HighWire. An advanced search strategy was used in the selection of the articles. Results: Evidence on the occurrence of significant changes in reproductive history and fertility in patients with proteinopathies of the nervous system were identified. Women with Parkinson´s disease and patients with Amyotrophic Lateral Sclerosis tend to show lower fertility than individuals in the general population. On the contrary, patients with Huntington´s disease or Spinocerebellar Ataxias tend to show higher fertility than individuals in the general population, with a significant role for nuptiality. On the other hand, women with Alzheimer´s disease usually show menopause at older ages whereas women with Parkinson´s disease usually show delayed menarche and a more reduced number of abortions than women in the general population.Conclusions: Available evidence regarding significant changes in the reproductive history and fertility in patients with proteinopathies of the nervous system are frequently contradictory and focused on biological factors with underestimation of socio-economic and cultural factors. Se conoce que varias proteinopatías del sistema nervioso se asocian a la ocurrencia de cambios significativos en la historia reproductiva y la fecundidad.Objetivo: Reflejar el comportamiento de la historia reproductiva y de la fecundidad en pacientes con proteinopatías del sistema nervioso.Material y Métodos: Se realizó una revisión bibliográfica entre los meses de enero de 2018 a diciembre de 2018. Se consultaron las bases de datos PubMed, EBSCO, Google Scholar y HighWire. Se empleó la estrategia de búsqueda avanzada para la selección de los artículos.Desarrollo: Se identificaron evidencias de ocurrencia de cambios significativos en la historia reproductiva y la fecundidad en pacientes con proteinopatías del sistema nervioso. Mientras que las mujeres con enfermedad de Parkinson y los pacientes con Esclerosis lateral amiotrófica tienden a tener una menor fecundidad que individuos de la población general, los pacientes con la enfermedad de