Data From QIN-Breast

This collection contains longitudinal PET/CT and quantitative MR images collected for the purpose of studying treatment assessment in breast cancer in the neoadjuvant setting. Images were acquired at three time points: prior to the start of treatment (t1), after the first cycle of treatment (t2), and either after the second cycle of treatment or at the completion of all treatments (prior to surgery) (t3). The PET/CT images were acquired with a support device built in-house to allow the patient to be in the prone position to facilitate registration with the MRI data. The value of this collection is to provide clinical imaging data for the development and evaluation of quantitative imaging methods for treatment assessment early in the course of therapy for breast cancer. Data is provided by Vanderbilt University, PI Dr. Thomas E. Yankeelov. PET/CT data were acquired with a GE Discovery STE scanner (GE Healthcare, Waukesha, WI, USA). A low-mAs CT scan was acquired for attenuation correction of the emission data. The acquisition parameters for the transmission CT scan were the following: the tube current was 80 mAs for a 70-kg patient and scaled accordingly for all patients, the tube voltage was 120 KVp, and the pitch was 1.675/1. The activity of FDG administered was approximately 370 MBq (10 mCi) for a 70-kg patient and scaled according to weight. FDG was administered intravenously via an antecubital vein contra-lateral to the affected breast. After 60 min, emission data was collected in 3D mode for 2 min per bed position. The emission scan was first collected in the prone position over the breast only, and then in the supine position from the skull to mid-femurs. Standard-of-care supine images and research prone images were acquired at times t1 and t3, while only the prone images were acquired at t2. The MRI data consist of diffusion-weighted images (DWIs), dynamic contrast-enhanced (DCE) images, and multi-flip data for T1-mapping. The MRIs were obtained using a dedicated 16-channel bilateral breast coil at 3.0T (Philips Achieva with the MammoTrak table). DWIs were acquired with a single-shot spin echo (SE) echo planar imaging (EPI) sequence in three orthogonal diffusion encoding directions (x, y, and z). For 14 patients, b = 0 and 500 s/mm2, TR/TE = 2500 ms/45 ms Δ = 21.4 ms, δ = 10.3 ms and 10 signal acquisitions were acquired. For 19 patients, b = 0 and 600 s/mm2, TR/TE = “shortest” (range = 1800 - 3083 ms/43 - 60 ms) Δ = 20.7 - 29 ms, δ = 11.4 - 21 ms an