Additional file 4: of Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

Additional file 4: of Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

Figure S4. ABI1 KO RWPE-1 cells exhibit no significant increase in proliferation but an upregulation of p-Akt. (A) Proliferation assays were performed at 2, 3 and 4 days post-plating in control RWPE-1 (parental and clone 16), ABI1 KO (clone 12 and 35), and ABI1 rescue (Iso2 and Iso3) cells, showing...

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Hauptverfasser: Nath, Disharee, Li, Xiang, Mondragon, Claudia, Post, Dawn, Chen, Ming, White, Julie, Hryniewicz-Jankowska, Anita, Caza, Tiffany, Kuznetsov, Vladimir, Hehnly, Heidi, Jamaspishvili, Tamara, Berman, David, Zhang, Fan, Kung, Sonia, Fazli, Ladan, Gleave, Martin, Bratslavsky, Gennady, Pandolfi, Pier, Kotula, Leszek
Format: Bild
Sprache:eng
Schlagworte:
Biochemistry
Cancer
Cell Biology
Developmental Biology
FOS: Biological sciences
Molecular Biology
Physiology
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Zusammenfassung:Figure S4. ABI1 KO RWPE-1 cells exhibit no significant increase in proliferation but an upregulation of p-Akt. (A) Proliferation assays were performed at 2, 3 and 4 days post-plating in control RWPE-1 (parental and clone 16), ABI1 KO (clone 12 and 35), and ABI1 rescue (Iso2 and Iso3) cells, showing no significant difference in proliferation rates (1-way ANOVA). (B) Western blot showing that p-Akt is increased in ABI1-null cells and can be stimulated by EGF after starvation. β-Actin was used as the loading control. (JPG 595 kb)
DOI:10.6084/m9.figshare.9871610