DCs accumulate with age in mice with lupus

Copyright information:Taken from "Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus"Arthritis Research & Therapy 2006;8(2):R49-R49.Published online 28 Feb 2006PMCID:PMC1526610. To study DCs, we analyzed the total population of splenocytes in mice 6 to 8 weeks old (young) and in mice 6 to 9 months old (old) and gated for CD11ccells that were negative for the B cell marker CD19. Percentages (b) and absolute numbers (c) of DCs gated as in (a). Each circle represents the percentage or absolute number of CD11ccells in one individual mouse, and the horizontal bars represent the average of each group. Results of the Mann-Whitney test analyses are shown. N.S. indicates > 0.05.