Genomic organization of the chicken /insulin locus on chromosome 5

Copyright information:Taken from "The regulated expression of chimeric tyrosine hydroxylase–insulin transcripts during early development"Nucleic Acids Research 2006;34(12):3455-3464.Published online 13 Jul 2006PMCID:PMC1524912.© 2006 The Author(s) () Schematic representation of the and insulin genes. Each box represents one exon and the exons are numbered. Open boxes indicate non-coding regions, the blue hatched boxes represent the coding exons and the pink solid boxes correspond to the insulin coding exons. Dashed lines represent RNA processing. Primers (P) used in PCR are indicated. () Schematic representation of the out-of-frame splicing between exon 13 and either exon 2 or 3 of the insulin gene. Nucleotide sequences at the end of exon 13 and the beginning of insulin exon 2 or 3 are shown together with the partial amino acid sequence of the TH isoforms; Asterisk indicates a stop codon. () Diagram of the insulin, TH and TH–INS transcripts. The stretch of 67 new amino acids of the TH–INS1 chimera is represented by the dotted box.