Additional file 17: of Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation

Figure S13. Canonical pathways involved in the inflammatory response to CuO materials. A differential expression analysis was performed in which each experimental group was compared against their respective PBS- or OVA-challenged control group. Activation z-scores of the predicted pathways with cut-offs of absolute z-score > 2 and -log(P value) > 2 were obtained from IPA and compared in PBS-challenged and OVA-challenged mice. A-D, 2D-scatterplots of canonical pathways affected by A) CuO, B) CuO COOH, C) CuO NH3 and D) CuO PEG exposure (40 μg/mouse) in PBS- and OVA-challenged mice. Top 5 pathways of each section with the highest z-scores have been denoted above or below the plot, and marked on the plot with a filled circle. Blue circles refer to correlated and red to anti-correlated pathways. Black circles indicate the pathways that had a z-score of zero in one of the data sets. (TIF 1108 kb)