(A) A two-step model; mRNA repression is triggered by specific mRNA-binding factors (GLD-1 and PUF-5)

Aggregation of repressed mRNPs reinforces repression by reducing rates of reentry of mRNAs into translation complexes (circular mRNPs on the left). CAR-1 may influence translation by controlling aggregation or mRNA targeting, or it could independently regulate translation and granule formation. (B) Granules as mRNP modification centers: Specific factors induce transient association of mRNAs with mRNP modification complexes where mRNPs exit in a repressed state; aggregation of these complexes into granules could improve efficiency of mRNP modification.Copyright information:Taken from "Maternal mRNAs are regulated by diverse P body–related mRNP granules during early development"The Journal of Cell Biology 2008;182(3):559-572.Published online 11 Aug 2008PMCID:PMC2500140.