Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes-4

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes-4

At received four intramuscular doses of naked DNA (400 μg), BCG or saline. Thirty days after the last dose, mice were challenged intra-tracheally with H37RV and 30 days post infection we performed histological analysis of the lung. (A) non-infected; (B) saline; (C) naked hsp65; (D) COMP-hsp65 and (E...

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Hauptverfasser: Rosada, Rogerio S, Lucimara Gaziola De La Torre, Fabiani G Frantz, Trombone, Ana PF, Zárate-Bladés, Carlos R, Fonseca, Denise M, Souza, Patrícia RM, Izaíra T Brandão, Masson, Ana P, Soares, Edson G, Ramos, Simone G, Faccioli, Lúcia H, Célio L Silva, Santana, Maria HA, Coelho-Castelo, Arlete AM
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Sprache:eng
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Molecular Biology
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Zusammenfassung:At received four intramuscular doses of naked DNA (400 μg), BCG or saline. Thirty days after the last dose, mice were challenged intra-tracheally with H37RV and 30 days post infection we performed histological analysis of the lung. (A) non-infected; (B) saline; (C) naked hsp65; (D) COMP-hsp65 and (E) BCG groups. Representative sections of HE staining. Magnifications: ×65.Copyright information:Taken from "Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes"http://www.biomedcentral.com/1471-2172/9/38BMC Immunology 2008;9():38-38.Published online 22 Jul 2008PMCID:PMC2500095.
DOI:10.6084/m9.figshare.86691