Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model-3

Scatter plot of total antioxidant reductive capacity and 8-oxo-dG lesions in matching samples showed a significant positive correlation for AC mice (r= 0.9094; P < 0.05), which was absent in the AH samples (r= 0.008383; P = 0.8836). () BER protein, APE/Ref-1 was expressed predominantly in the connective tissue of the MMTV-PyMT tumours. () Total positive staining area for APE/Ref-1 in tumour tissue (excluding connective tissue) did not differ in tissues from acute hypoxia and air control exposed mice. Bars: median with interquartile range. Scale bar: 50 μm.Copyright information:Taken from "Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model"http://www.biomedcentral.com/1471-2407/8/151BMC Cancer 2008;8():151-151.Published online 28 May 2008PMCID:PMC2427038.