(A) Weight loss curves of mouse recipients of WT T cells treated with either 100 μg anti-BTLA mAb (clone 6F7) or IgG1 isotype control twice a week beginning at the time of T cell transfer

Data shown represent the average of four mice in each group and are representative of two independent experiments. (B) Histological scoring performed 3 wk after T cell transfer revealed milder intestinal inflammation in samples obtained from animals treated with the anti-BTLA mAb. Each circle represents a single mouse in a total of eight mice per group. *, P < 0.05. (C) Same as A, except that animals were transferred with CD4CD45RB T cells. (D) Histological analysis 3 wk after transfer revealed equivalent intestinal inflammation in all transferred animals regardless of the treatment with the anti-BTLA mAb. Each circle represents a single mouse in a total of five mice per group.Copyright information:Taken from "A crucial role for HVEM and BTLA in preventing intestinal inflammation"The Journal of Experimental Medicine 2008;205(6):1463-1476.Published online 9 Jun 2008PMCID:PMC2413041.