Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain-5

4 and 48 hours. Treatment with compound C inhibited AMPK phosphorylation and increased caspase-3 cleavage in astrocytes. b) Astrocytes were cultured with 1.0 mM glucose containing media in the presence or absence of 0.5 and 1.0 mM of AICAR for 72 hours. Treatment with AICAR significantly increased the number of astrocytes in a dose dependent manner as detected by fluorescence from calcein labeled astrocytes at p < 0.001.Copyright information:Taken from "Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain"http://www.molecular-cancer.com/content/7/1/37Molecular Cancer 2008;7():37-37.Published online 12 May 2008PMCID:PMC2397440.