Base-specific interactions of wild-type MutS with CDDP-DNA

Copyright information:Taken from "The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response"Nucleic Acids Research 2006;34(8):2173-2185.Published online 28 Apr 2006PMCID:PMC1450329.© The Author 2006. Published by Oxford University Press. All rights reserved Gold sphere: cisplatinum. Shown are Phe36 and Glu38 () in their orientation towards the cross-linked guanines. Hydrogen bonds between Glu38 and the guanines are indicated. () Both hydrogen bonds that can be formed between Glu38 and either one of the cross-linked guanines. () and () The alternate hydrogen bonds formed between Glu38 and one of the cisplatin-cross-linked guanines. The local distortions induced by either conformation are indicated.