Zebrafish and are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence-5

Sion is seen in embryos of 2 cell (A), 16 cell (B), 30% epiboly (C), and bud (D) stages for both (shown) and (not shown) genes. Enriched expression in "ladder" patterns along the developing neural keel/rod during segmentation is seen in 14 somite embryos probed for (E) and for (M). Cross-sections of 14 somite whole mount embryos probed for (I, schematic with real image below; 5–6 somite level) show enriched expression in ventrolateral neural rod (nr), floorplate above notochord (nc), and ventral somites (s). Expression is most prominent in head region of 18 somite embyros for both paralogs (F, G; and N, O); only is also enriched in tail bud (F), while remains high along the entire ventral trunk (N) at this stage. By 24 hours, is prominent in the entire head, with some expression in ventral trunk and post-anal tail (H), while is enriched in ventral brain, cerebellum, and ventral trunk, with low level ubiquitous expression (P). Dorsal flat mounts of 24 hour embryos (J, K) show expression enriched within caudal tectum (t) at hindbrain-midbrain boundary, within specific cells of the cerebellum (cb) and at the caudal border between cerebellum and rest of hindbrain. The image in (K) is a higher magnification view of a region from another embryo equivalent to the boxed region in J. Expression of in cells of otic vesicle walls (ov) is apparent both in flat mounts (J) and cross sections at that level (L). Bar = 250 μm for A-H, J, M-P; = 50 μm for I, K; = 100 μm for L.Copyright information:Taken from "Zebrafish and are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence"http://www.biomedcentral.com/1471-213X/8/39BMC Developmental Biology 2008;8():39-39.Published online 10 Apr 2008PMCID:PMC2373290.