Zebrafish and are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence-3

Nio (chr16.1 or chr16.2 for simBrd2; and Brd2b), Onchorynchus (Oncho2L for Brd2L) and Oryzias (OryzUn for Brd), are shown below consensus sequences (top line of each section, in bold), for bromodomain 1 (Bromo 1; 60 amino acid core), bromodomain 2 (Bromo 2; 60 amino acid core) and ET domain (ET; first 120 amino acids). Amino acid numbers at right show position relative to entire protein. Residues within domains that differ from consensus are shown in bold. Asteriks (*) denote bromodomain residues important for acetyl lysine-binding [3]. Dots (.) denote residues important for BD1/BD1 dimerization [32]. (--) shows varying residues in paralogs in ZA loop region. Danio is represented by zf626/Brd2 (Danio), and paralogous proteins encoded by ENSDART00000049051 (chr16.1, bromo 1 and 2), GENSCAN00000006161 (chr16.2, ET domain), and BC055508.1 cDNA (Brd2b; ends prematurely before ET domain). Sequences used here are translations of those used to construct phylogenetic trees (see Fig. 3 legend).Copyright information:Taken from "Zebrafish and are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence"http://www.biomedcentral.com/1471-213X/8/39BMC Developmental Biology 2008;8():39-39.Published online 10 Apr 2008PMCID:PMC2373290.