Zebrafish and are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence-1

6) from the Tubingen strain, zebrafish chromosome 19 from the AB strain (Dr chr 19/AB), and Onchorynchus chromosome 2 (Om chr 2). Gene order is derived from contig views in Vega (Dr chr 19, Dr chr 19/AB), Ensembl (Dr chr 16, Hs chr 6, NA1181), direct reading of annotated genomic clones (Dr chr 19, BX510994.6; Dr chr 19/AB, AL672176.10), and reference 28 (Om chr 2). Brd2-related genes are shown in bold. Genes that reside on the same genomic clone are shown in single-spaced groups; genomic clones within the same chromosome that physically overlap are connected by vertical lines. Related genes or groups of genes between chromosomes that show conserved synteny are also connected by lines. Human resides within the MHC II complex on chromosome 6, in a conserved syntenic block between and genes; zebrafish is found in the same gene block within the fish MHC I core on chromosome 19, and is the true ortholog of mammalian . Gene content on chromosome 19 from strains Tubingen and AB differs outside the and the gene blocks, and may indicate recent genomic rearrangement. The zebrafish paralogous locus on chromosome 16 (alias loc 569354, ) is linked to sequences and other MHC II and III related genes, as is trout on chromosome 2, presumably representing the ancestral vertebrate configuration. on unmapped scaffold NA1181 consists of two exons encoding the second bromodomain of partial cDNA (GenBank: ), and with further genome assembly will likely be shown to derive from the same locus on chromosome 16.Copyright information:Taken from "Zebrafish and are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence"http://www.biomedcentral.com/1471-213X/8/39BMC Developmental Biology 2008;8():39-39.Published online 10 Apr 2008PMCID:PMC2373290.