Application of an mGluR5 antagonist either prior to or after HFT prevented LTP in the CA1 region

(A) HFT (100 Hz) induced persistent LTP (which lasted for at least 4 h) in the CA1 region . Application of the mGluR5 antagonist MPEP (40 µ), for 20 min prior to HFT, significantly prevented both the induction and the expression of LTP. Application of MPEP (40 µ) for 20 min after HFT significantly prevented the expression of LTP beyond 2 h post-HFT. Bar indicates drug application before (black) or after (grey) HFT. (B) Application of MPEP (40 µ) did not affect basal synaptic transmission compared to controls. Bar indicates drug application. Insets: evoked potentials obtained in the presence of vehicle or MPEP (applied pre-HFT) at the timepoints noted: vertical bars, 2 mV; horizontal bars, 2 ms.Copyright information:Taken from "Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region "The European Journal of Neuroscience 2008;27(6):1345-1352.Published online 01 Mar 2008PMCID:PMC2327219.© The Authors (2008) Journal compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd