Association of FOSL1 copy number alteration and triple negative breast tumors

Abstract Copy number alterations (CNAs) are a frequent feature in human breast cancer, and one of the hallmarks of genomic instability. The FOSL1, GSTP1 and CCND1 genes are located at 11q13, a cytoband commonly affected by CNA in breast cancer, with relevant function in progression and invasion. Our...

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Hauptverfasser:	Serino, Leandro Tamião Rodrigues, Tayana Schultz Jucoski, Morais, Stephanie Bath De, Fernandes, Cíntia Callegari Coêlho, Lima, Rubens Silveira De, Cícero Andrade Urban, Cavalli, Luciane Regina, Iglenir João Cavalli, Enilze Maria De Souza Fonseca Ribeiro
Format:	Dataset
Sprache:	eng
Schlagworte:	Biochemistry and Cell Biology not elsewhere classified FOS: Biological sciences Genetics not elsewhere classified
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Zusammenfassung:	Abstract Copy number alterations (CNAs) are a frequent feature in human breast cancer, and one of the hallmarks of genomic instability. The FOSL1, GSTP1 and CCND1 genes are located at 11q13, a cytoband commonly affected by CNA in breast cancer, with relevant function in progression and invasion. Our main goal was to analyze CNAs of these genes and determine their association with breast cancer subtypes. Seventy-three cases of invasive breast tumors [52 Luminal, 7 HER2+ and 14 triple negative (TNBC) subtypes] were analyzed by TaqMan assays. CNAs were observed for all genes, with gains more frequently observed. Gains of the FOSL1 gene were observed in 71% of the cases. This gene was the only one with a statistically significant difference (p
DOI:	10.6084/m9.figshare.7806641