Metadata and data files supporting 'FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype'

This data record describes the data files supporting the related publication "FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype" and contains clinicopathologic, FGFR4 expression and FGFR4 hotspot mutationallele frequency data files.The related study investigates acquired resistance to endocrine therapy in Invasive lobular carcinoma (ILC); a common histological subtype in which most tumours are ER+ and so treated with endocrine therapy. Study design summaryThe related study is a subset analysis of existing RNA sequencing focusing only on ER+ patients treated with endocrine therapy prior to recurrence, and reporting additional FGFR4 expression data from paired gastrointestinal (GI) and ovarian metastases.Sample size26 patients. Treatment-naïve primary tumors and 29 endocrine-treated metastases, consisting of 7 bone, 7 brain, 5 GI, and 10 ovarian metastases were collected.Data access:For all data requests please contact:Prof Steffi OesterreichWomen’s Cancer Research CenterMagee Women’s Research InstituteCraft Avenue, Room B705Pittsburgh, PA 15213, USATel: 412-641-8555oesterreichs@upmc.eduRaw RNA-Seq data for the paired primary and metastatic samples will be made available upon request and under regulatory compliance via DUAData files and formatsData supporting figure 1A: files or repository identifiers: mm134_qpcr.xlsx, sum44_qpcr.xlsformat: MS Excellocation of data file(s): Institutional file storagedata access: Contact Prof Oesterreich with data requestsdescription: FGFR4 expression in endocrine-resistant cell linessee also: LTED and Tamoxifen resistant cell line expression data belowData supporting figure 1B: files or repository identifiers: Supplementary Table S1.xlsxformat: MS Excellocation of data file(s): figshare (this data record)data access: publicly accessibledescription: FGFR4 Expression in Paired ER+Endocrine−Treated Breast Metastasessee also: section on RNA-Seq expressionData supporting figure 2A-D: files or repository identifiers: FGFR4_allVUS_3_13_2018.csvformat: CSV text filelocation of data file(s): institutional file storagedata access: contact Prof Oesterreich with data requestssee also: FGFR4 mutations data belowdescription: FGFR4 mutations in breast metastases, FGFR4 hotspot mutations (N535, V550) in breast metastases vs non-breast metastases, FGFR4 hotspot mutations in metastatic IDC vs metastatic ILC and FGFR4 hotspot mutations in endocrine-treated metastasesData supporting s