Additional file 3: of Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion

The small orally available sortilin inhibitor AF38469 do not impact cell viability. Relative proliferation of MCF7 and MDA-MB 231 cells 48 h after treatment with vehicle (PBS/DMSO), AF38469 (3 μg/ml), progranulin (PGRN) (1 μg/ml) or AF38469 (3 μg/ml) and PGRN (1 μg/ml) by Alamar Blue assay. (TIFF 13...

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Hauptverfasser:	Rhost, Sara, Éamon Hughes, Harrison, Hannah, Svanheidur Rafnsdottir, Jacobsson, Hanna, Gregersson, Pernilla, Magnusson, Ylva, Fitzpatrick, Paul, Andersson, Daniel, Berger, Karoline, Ståhlberg, Anders, Landberg, Göran
Format:	Bild
Sprache:	eng
Schlagworte:	Biochemistry Biotechnology Cancer Chemical Sciences not elsewhere classified Developmental Biology FOS: Biological sciences FOS: Chemical sciences FOS: Health sciences FOS: Mathematics Hematology Infectious Diseases Mathematical Sciences not elsewhere classified Microbiology Molecular Biology Pharmacology Plant Biology
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Zusammenfassung:	The small orally available sortilin inhibitor AF38469 do not impact cell viability. Relative proliferation of MCF7 and MDA-MB 231 cells 48 h after treatment with vehicle (PBS/DMSO), AF38469 (3 μg/ml), progranulin (PGRN) (1 μg/ml) or AF38469 (3 μg/ml) and PGRN (1 μg/ml) by Alamar Blue assay. (TIFF 134 kb)
DOI:	10.6084/m9.figshare.7362620