Increased susceptibility to DSS colitis in ZBP-89 mice

Copyright information:Taken from "An isoform of ZBP-89 predisposes the colon to colitis"Nucleic Acids Research 2006;34(5):1342-1350.Published online 3 Mar 2006PMCID:PMC1390687.© The Author 2006. Published by Oxford University Press. All rights reserved (–) Representative H&E stains of normal (), heterozygous () and ZBP-89 () mice. Inf = infiltrating lymphocytes; SE = submucosal edema; TM = transmural inflammation. () ΔNter expression accelerates onset of gastrointestinal bleeding, measured by fecal occult blood screening. () Mortality during DSS treatment: 50% of ZBP-89/ZBP-89 mice die during 4% DSS treatment; all ZBP-89/ZBP-89 and ZBP-89/ZBP-89 mice survived (six in each group). () Colitis index scoring of DSS-treated mice, as described in Materials and Methods; six mice in each genotype cohort.