Mixed-effect model representation of gene expression over time

Copyright information:Taken from "A data-driven clustering method for time course gene expression data"Nucleic Acids Research 2006;34(4):1261-1269.Published online 1 Mar 2006PMCID:PMC1388097.© The Author 2006. Published by Oxford University Press. All rights reserved The deviation of gene 's expression from the mean curve μ() in cluster , is a combination of the so-called random effect and the measurement error ɛ. Ψ represents the ‘real’ expression curve of gene 1. Note that the is constant over all time-points and captures between time-point dependence.