Additional file 6: of Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Figure S4. SOCS3 regulates gene networks linked to reactivity in APP astrocytes. The top 100 most connected genes of the WGCNA module were analyzed for protein-protein interaction networks with STRING. Groups of proteins related to complement system and inflammation, cytoskeleton and cell adhesion w...

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Hauptverfasser: Ceyzériat, Kelly, Haim, Lucile Ben, Denizot, Audrey, Pommier, Dylan, Matos, Marco, Guillemaud, Océane, Marie-Ange Palomares, Laurene Abjean, Petit, Fanny, Gipchtein, Pauline, Marie-Claude Gaillard, Guillermier, Martine, Sueva Bernier, Gaudin, Mylène, Aurégan, Gwenaëlle, Joséphine, Charlène, Déchamps, Nathalie, Veran, Julien, Langlais, Valentin, Cambon, Karine, Bemelmans, Alexis, Baijer, Jan, Bonvento, Gilles, Dhenain, Marc, Jean-François Deleuze, Oliet, Stéphane, Brouillet, Emmanuel, Hantraye, Philippe, Maria-Angeles Carrillo-De Sauvage, Olaso, Robert, Panatier, Aude, Escartin, Carole
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Zusammenfassung:Figure S4. SOCS3 regulates gene networks linked to reactivity in APP astrocytes. The top 100 most connected genes of the WGCNA module were analyzed for protein-protein interaction networks with STRING. Groups of proteins related to complement system and inflammation, cytoskeleton and cell adhesion were found co-regulated by SOCS3 (circles). Protein-protein interaction p value
DOI:10.6084/m9.figshare.7210679