Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis-1

Copyright information:Taken from "Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis"http://www.translational-medicine.com/content/5/1/63Journal of Translational Medicine 2007;5():63-63.Published online 5 Dec 2007PMCID:PMC2234395.phaSMA- (SMA) and vimentin-positive (VIM) structures are endothelia, CD31 staining was performed. (D-F) In areas of loosely packed mononuclear cells (arrowhead in D) and packed mononuclear cells (white arrow in D), there is sparse immunoreactivity for collagen1 (arrowhead and white arrow in E) and moderate staining for fibronectin (arrowhead and white arrow in F). In areas with a low number of CD45-positive mononuclear cells (dotted arrow in D), the staining intensities for collagen1 (dotted arrow in E; COL) and fibronectin (dotted arrow in F; FBN) are stronger. Original magnification: ×200.