The effect of drug combinations on comet tail formation

Copyright information:Taken from "Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage"Nucleic Acids Research 2006;34(4):1148-1157.Published online 16 Feb 2006PMCID:PMC1373695.© The Author 2006. Published by Oxford University Press. All rights reserved HCT116 cells were treated with etoposide, geldanamycin or a combination of the two over a period of 24 h and the comet tails lengths of 25 cells per drug treatment were determined. () Demonstrates the average comet tail length variation over time. Black line and diamond = untreated control; blue line and square = etoposide only treatment; green line and triangle = geldanamycin only treatment; red line and cross = geldanamycin and etoposide combined treatment. () Demonstrates the distribution of comet tail lengths over time with the doses as indicated.