Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard devi...

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Hauptverfasser:	Wang, Yunzhang, Karlsson, Robert, Lampa, Erik, Zhang, Qian, Hedman, Åsa K., Almgren, Malin, Almqvist, Catarina, F. McRae, Allan, E. Marioni, Riccardo, Ingelsson, Erik, M. Visscher, Peter, J. Deary, Ian, Lind, Lars, Morris, Tiffany, Beck, Stephan, L. Pedersen, Nancy, Hägg, Sara
Format:	Dataset
Sprache:	eng
Schlagworte:	Biological Sciences not elsewhere classified Environmental Sciences not elsewhere classified FOS: Biological sciences Genetics Medicine Mental Health
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Zusammenfassung:	Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic and 96 dizygotic pairs) up to five times (mean 2.6) over 20 years (mean 8.7). We identified 1316 age-associated methylation sites (P
DOI:	10.6084/m9.figshare.7145891