Application of an mGluR1 antagonist prior to, but not after, LFS prevented LTD in the CA1 region

LFS (2 Hz, 1200 pulses) induced persistent LTD which lasted for at least 4 h in the CA1 region . Application of the mGluR1 antagonist LY367285 (100 µ), for 20 min prior to LFS, significantly impaired the induction and expression phases of LTD. Application of the mGluR1 antagonist LY367285 (100 µ) for 20 min after LFS had no effect on the profile of LTD. Bar indicates drug application before (black) or after (grey) LFS. Insets: evoked potentials obtained in the presence of LY387385 applied pre-HFT or LY387385 applied post-HFT at the timepoints noted: vertical bars, 2 mV; horizontal bars, 2 ms.Copyright information:Taken from "Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region "The European Journal of Neuroscience 2008;27(6):1345-1352.Published online 01 Mar 2008PMCID:PMC2327219.© The Authors (2008) Journal compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd