Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome-3

Copyright information:Taken from "Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome"http://www.biomedcentral.com/1471-2172/8/28BMC Immunology 2007;8():28-28.Published online 13 Nov 2007PMCID:PMC2211507.omic DNA of Pt.1 and Pt.2. Circles represent females; squares, males; subjects carrying a CASP10 mutation are marked in black, those with a TNFRSF6 are marked with striped lines. Numbers indicate the cell survival upon Fas triggering by mAb in T cell lines generated form each subject; Fas function was defective in Pt.1 and borderline in the other subjects (normal values of cell survival: median 60%, 95percentile 82%)