Epstein-Barr virus latency switch in human B-cells: a physico-chemical model-3

Copyright information:Taken from "Epstein-Barr virus latency switch in human B-cells: a physico-chemical model"http://www.biomedcentral.com/1752-0509/1/40BMC Systems Biology 2007;1():40-40.Published online 31 Aug 2007PMCID:PMC2164963.t time zero the system is stable in latency I, with an EBNA-1 level of 850 molecules, and an Oct-2 level of 15000 molecules. Transition to latency III is induced by lowering the Oct-2 level to 10000, activating the C promoter. Reaching the stable latency III level of EBNA-1 proteins thereafter take a few days. Induced switching back to resting latency I state demands a distinct increase in Oct-2, minimum a 10 fold change (green solid line). The greater increase in Oct-2 molecules the faster the cell is switched back to a stable latency I level of EBNA-1. The green solid and dashed line illustrate two different scenarios of elevated Oct-2 levels, where the red solid and dashed line are the corresponding resulting EBNA-1 levels.