Electron micrographs showing the integrin alphavbeta3 immunogold labeling in epithelial cells of primary cultures of normal breast tissues (A, B) and of breast cancer biopsies (C, D)

Copyright information:Taken from "Altered expression pattern of integrin alphavbeta3 correlates with actin cytoskeleton in primary cultures of human breast cancer"http://www.cancerci.com/content/7/1/16Cancer Cell International 2007;7():16-16.Published online 2 Oct 2007PMCID:PMC2116995. In both cases staining pattern is essentially the same i.e. mostly single gold particles (arrows), and occasionally aggregates (arrowheads) over the region of the stress fibers. However, in cancer epithelial cells an increased integrin alphavbeta3 immunogold labeling is observed. [25,250×].