An AICD-based functional screen to identify APP metabolism regulators-5

Copyright information:Taken from "An AICD-based functional screen to identify APP metabolism regulators"http://www.molecularneurodegeneration.com/content/2/1/15Molecular Neurodegeneration 2007;2():15-15.Published online 24 Aug 2007PMCID:PMC2071909.increases AICD-Gal4 production compared to empty vector controls. (B) Knock-down of Fe65 or Tip60 in SY5Y-APP-Gal4 cells decreases AICD-Gal4 mediated luciferase activity Bars represent the mean normalized luciferase activity of four independent trials and error bars represent standard errors. Statistical significance was determined using two-sample, one-tailed t-tests to compare each secretase gene and "vector" or "control" and sequential Bonferroni procedure to adjust for multiple comparisons. * indicates p < 0.05.