Vertical Transmission of HIV-1 in the Metropolitan Area of Belo Horizonte, Brazil: 2006-2014
Abstract Objective To revise HIV-1 vertical transmission (VT) rates in the metropolitan area of Belo Horizonte, Brazil, from January of 2006 to December of 2014. Methods Descriptive study of a prospective cohort of HIV-1-infected pregnant women and their children, monitored by the Maternal and Child...
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creator | Melo, Victor Hugo Maia, Marcelle Marie Martins Júnior, Mário Dias Correa Kakehasi, Fabiana Maria Ferreira, Flávia Gomes Faleiro Andrade, Beatriz Amélia Monteiro De Scaramussa, Fernanda Sobral Ferreira, Fernanda Alves Morais Messias, Alfredo Augusto Pinto, Jorge Andrade |
description | Abstract Objective To revise HIV-1 vertical transmission (VT) rates in the metropolitan area of Belo Horizonte, Brazil, from January of 2006 to December of 2014. Methods Descriptive study of a prospective cohort of HIV-1-infected pregnant women and their children, monitored by the Maternal and Child HIV/Aids Research Group of Research Group at Faculty of Medicine of Universidade Federal de Minas Gerais, Brazil. Results The VT general rate was 1.9% (13/673; confidence interval [CI] 95%: 1.0-3.3). The extensive use of combined highly active antiretroviral therapy (HAART) (89.7%; 583/650) strongly impacted the reduction of VT during this period. Maternal viral load (VL) higher than 1,000 copies/mL showed significant association with VT (OR:6.6; CI 95%:1.3-33.3). Maternal breastfeeding was described in 10 cases in this cohort (1.5%; CI 95%: 0.7-2.7), but it was not associated with VT. Conclusion The present cohort data were coherent with the low VT rate described in other global populations, and it was considerably lower in comparison to the results of the same cohort during the period of 1998-2005, when the VT rate was 6.2%. These data confirm the efficiency of the National Guidelines, and emphasize the importance of adopting the international recommended procedures for prevention of mother-tochild transmission (MTCT) of HIV. |
doi_str_mv | 10.6084/m9.figshare.6448376 |
format | Dataset |
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Methods Descriptive study of a prospective cohort of HIV-1-infected pregnant women and their children, monitored by the Maternal and Child HIV/Aids Research Group of Research Group at Faculty of Medicine of Universidade Federal de Minas Gerais, Brazil. Results The VT general rate was 1.9% (13/673; confidence interval [CI] 95%: 1.0-3.3). The extensive use of combined highly active antiretroviral therapy (HAART) (89.7%; 583/650) strongly impacted the reduction of VT during this period. Maternal viral load (VL) higher than 1,000 copies/mL showed significant association with VT (OR:6.6; CI 95%:1.3-33.3). Maternal breastfeeding was described in 10 cases in this cohort (1.5%; CI 95%: 0.7-2.7), but it was not associated with VT. Conclusion The present cohort data were coherent with the low VT rate described in other global populations, and it was considerably lower in comparison to the results of the same cohort during the period of 1998-2005, when the VT rate was 6.2%. These data confirm the efficiency of the National Guidelines, and emphasize the importance of adopting the international recommended procedures for prevention of mother-tochild transmission (MTCT) of HIV.</description><identifier>DOI: 10.6084/m9.figshare.6448376</identifier><language>eng</language><publisher>SciELO journals</publisher><subject>FOS: Clinical medicine ; Obstetrics and Gynaecology</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,1894</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.6448376$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Melo, Victor Hugo</creatorcontrib><creatorcontrib>Maia, Marcelle Marie Martins</creatorcontrib><creatorcontrib>Júnior, Mário Dias Correa</creatorcontrib><creatorcontrib>Kakehasi, Fabiana Maria</creatorcontrib><creatorcontrib>Ferreira, Flávia Gomes Faleiro</creatorcontrib><creatorcontrib>Andrade, Beatriz Amélia Monteiro De</creatorcontrib><creatorcontrib>Scaramussa, Fernanda Sobral</creatorcontrib><creatorcontrib>Ferreira, Fernanda Alves Morais</creatorcontrib><creatorcontrib>Messias, Alfredo Augusto</creatorcontrib><creatorcontrib>Pinto, Jorge Andrade</creatorcontrib><title>Vertical Transmission of HIV-1 in the Metropolitan Area of Belo Horizonte, Brazil: 2006-2014</title><description>Abstract Objective To revise HIV-1 vertical transmission (VT) rates in the metropolitan area of Belo Horizonte, Brazil, from January of 2006 to December of 2014. Methods Descriptive study of a prospective cohort of HIV-1-infected pregnant women and their children, monitored by the Maternal and Child HIV/Aids Research Group of Research Group at Faculty of Medicine of Universidade Federal de Minas Gerais, Brazil. Results The VT general rate was 1.9% (13/673; confidence interval [CI] 95%: 1.0-3.3). The extensive use of combined highly active antiretroviral therapy (HAART) (89.7%; 583/650) strongly impacted the reduction of VT during this period. Maternal viral load (VL) higher than 1,000 copies/mL showed significant association with VT (OR:6.6; CI 95%:1.3-33.3). Maternal breastfeeding was described in 10 cases in this cohort (1.5%; CI 95%: 0.7-2.7), but it was not associated with VT. Conclusion The present cohort data were coherent with the low VT rate described in other global populations, and it was considerably lower in comparison to the results of the same cohort during the period of 1998-2005, when the VT rate was 6.2%. These data confirm the efficiency of the National Guidelines, and emphasize the importance of adopting the international recommended procedures for prevention of mother-tochild transmission (MTCT) of HIV.</description><subject>FOS: Clinical medicine</subject><subject>Obstetrics and Gynaecology</subject><fulltext>true</fulltext><rsrctype>dataset</rsrctype><creationdate>2018</creationdate><recordtype>dataset</recordtype><sourceid>PQ8</sourceid><recordid>eNo1z7FOwzAUhWEvDKjwBCx-ABLs2HFstrYCUqkVS9QJybpxrqmlJK4cL_TpUUWZzvLrSB8hT5yVimn5MpnSh-_lBAlLJaUWjbonX0dMOTgYaZdgXqawLCHONHra7o4Fp2Gm-YT0gDnFcxxDhpmuE8K12OAYaRtTuMQ54zPdJLiE8ZVWjKmiYlw-kDsP44KPt12R7v2t27bF_vNjt13vi0EbVZhBonEIxhlVN6LWXAFjrKkrMXiHSpheOd17b3rZK-G9Vii5bCoOtQTNxYqIv9sBMriQ0Z5TmCD9WM7slW4nY__p9kYXvx3JUyo</recordid><startdate>20180606</startdate><enddate>20180606</enddate><creator>Melo, Victor Hugo</creator><creator>Maia, Marcelle Marie Martins</creator><creator>Júnior, Mário Dias Correa</creator><creator>Kakehasi, Fabiana Maria</creator><creator>Ferreira, Flávia Gomes Faleiro</creator><creator>Andrade, Beatriz Amélia Monteiro De</creator><creator>Scaramussa, Fernanda Sobral</creator><creator>Ferreira, Fernanda Alves Morais</creator><creator>Messias, Alfredo Augusto</creator><creator>Pinto, Jorge Andrade</creator><general>SciELO journals</general><scope>DYCCY</scope><scope>PQ8</scope></search><sort><creationdate>20180606</creationdate><title>Vertical Transmission of HIV-1 in the Metropolitan Area of Belo Horizonte, Brazil: 2006-2014</title><author>Melo, Victor Hugo ; Maia, Marcelle Marie Martins ; Júnior, Mário Dias Correa ; Kakehasi, Fabiana Maria ; Ferreira, Flávia Gomes Faleiro ; Andrade, Beatriz Amélia Monteiro De ; Scaramussa, Fernanda Sobral ; Ferreira, Fernanda Alves Morais ; Messias, Alfredo Augusto ; Pinto, Jorge Andrade</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d896-9d4e9cea9c965735816a0007523dfce639b6c8bff9b4b63ff86e414721a54a813</frbrgroupid><rsrctype>datasets</rsrctype><prefilter>datasets</prefilter><language>eng</language><creationdate>2018</creationdate><topic>FOS: Clinical medicine</topic><topic>Obstetrics and Gynaecology</topic><toplevel>online_resources</toplevel><creatorcontrib>Melo, Victor Hugo</creatorcontrib><creatorcontrib>Maia, Marcelle Marie Martins</creatorcontrib><creatorcontrib>Júnior, Mário Dias Correa</creatorcontrib><creatorcontrib>Kakehasi, Fabiana Maria</creatorcontrib><creatorcontrib>Ferreira, Flávia Gomes Faleiro</creatorcontrib><creatorcontrib>Andrade, Beatriz Amélia Monteiro De</creatorcontrib><creatorcontrib>Scaramussa, Fernanda Sobral</creatorcontrib><creatorcontrib>Ferreira, Fernanda Alves Morais</creatorcontrib><creatorcontrib>Messias, Alfredo Augusto</creatorcontrib><creatorcontrib>Pinto, Jorge Andrade</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Melo, Victor Hugo</au><au>Maia, Marcelle Marie Martins</au><au>Júnior, Mário Dias Correa</au><au>Kakehasi, Fabiana Maria</au><au>Ferreira, Flávia Gomes Faleiro</au><au>Andrade, Beatriz Amélia Monteiro De</au><au>Scaramussa, Fernanda Sobral</au><au>Ferreira, Fernanda Alves Morais</au><au>Messias, Alfredo Augusto</au><au>Pinto, Jorge Andrade</au><format>book</format><genre>unknown</genre><ristype>DATA</ristype><title>Vertical Transmission of HIV-1 in the Metropolitan Area of Belo Horizonte, Brazil: 2006-2014</title><date>2018-06-06</date><risdate>2018</risdate><abstract>Abstract Objective To revise HIV-1 vertical transmission (VT) rates in the metropolitan area of Belo Horizonte, Brazil, from January of 2006 to December of 2014. Methods Descriptive study of a prospective cohort of HIV-1-infected pregnant women and their children, monitored by the Maternal and Child HIV/Aids Research Group of Research Group at Faculty of Medicine of Universidade Federal de Minas Gerais, Brazil. Results The VT general rate was 1.9% (13/673; confidence interval [CI] 95%: 1.0-3.3). The extensive use of combined highly active antiretroviral therapy (HAART) (89.7%; 583/650) strongly impacted the reduction of VT during this period. Maternal viral load (VL) higher than 1,000 copies/mL showed significant association with VT (OR:6.6; CI 95%:1.3-33.3). Maternal breastfeeding was described in 10 cases in this cohort (1.5%; CI 95%: 0.7-2.7), but it was not associated with VT. Conclusion The present cohort data were coherent with the low VT rate described in other global populations, and it was considerably lower in comparison to the results of the same cohort during the period of 1998-2005, when the VT rate was 6.2%. These data confirm the efficiency of the National Guidelines, and emphasize the importance of adopting the international recommended procedures for prevention of mother-tochild transmission (MTCT) of HIV.</abstract><pub>SciELO journals</pub><doi>10.6084/m9.figshare.6448376</doi><oa>free_for_read</oa></addata></record> |
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subjects | FOS: Clinical medicine Obstetrics and Gynaecology |
title | Vertical Transmission of HIV-1 in the Metropolitan Area of Belo Horizonte, Brazil: 2006-2014 |
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