Additional file 3: of KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2
Immunostaining of K1 papyllary thyroid cells with p300 antibody after 72 h of treatment with CPTH2 (100 μM) compared to untreated and DMSO controls. Apoptotic percentage of 786-O cells treated with proteasome inhibitor MG-132 (1 h) and then incubated in DMSO w/w CPTH2 shows no significative changes...
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| creator | Cocco, Elisa Leo, Manuela Canzonetta, Claudia Vito, Serena Di Mai, Antonello Rotili, Dante Napoli, Arianna Di Vecchione, Andrea Nunzio, Cosimo De Filetici, Patrizia Stoppacciaro, Antonella |
| description | Immunostaining of K1 papyllary thyroid cells with p300 antibody after 72 h of treatment with CPTH2 (100 μM) compared to untreated and DMSO controls. Apoptotic percentage of 786-O cells treated with proteasome inhibitor MG-132 (1 h) and then incubated in DMSO w/w CPTH2 shows no significative changes of the apoptotic profiles compared to the untreated controls. p300 immunostaining of 786-O cells were pretreated for 1 h with proteasome inhibitor MG132, then grow in DMSO w/w CPTH2 for 18 h suggest that there is no significative proteolysis of p300 upon inhibition of the proteasome. (TIFF 30444 kb) |
| doi_str_mv | 10.6084/m9.figshare.6094199 |
| format | Image |
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Apoptotic percentage of 786-O cells treated with proteasome inhibitor MG-132 (1 h) and then incubated in DMSO w/w CPTH2 shows no significative changes of the apoptotic profiles compared to the untreated controls. p300 immunostaining of 786-O cells were pretreated for 1 h with proteasome inhibitor MG132, then grow in DMSO w/w CPTH2 for 18 h suggest that there is no significative proteolysis of p300 upon inhibition of the proteasome. 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Apoptotic percentage of 786-O cells treated with proteasome inhibitor MG-132 (1 h) and then incubated in DMSO w/w CPTH2 shows no significative changes of the apoptotic profiles compared to the untreated controls. p300 immunostaining of 786-O cells were pretreated for 1 h with proteasome inhibitor MG132, then grow in DMSO w/w CPTH2 for 18 h suggest that there is no significative proteolysis of p300 upon inhibition of the proteasome. 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| subjects | Biochemistry Biotechnology Cancer Cell Biology Chemical Sciences not elsewhere classified Developmental Biology FOS: Biological sciences FOS: Chemical sciences FOS: Clinical medicine Genetics Hematology Immunology Microbiology Molecular Biology Neuroscience Pharmacology Physiology |
| title | Additional file 3: of KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 |
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