Additional file 3: of KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2

Immunostaining of K1 papyllary thyroid cells with p300 antibody after 72 h of treatment with CPTH2 (100 μM) compared to untreated and DMSO controls. Apoptotic percentage of 786-O cells treated with proteasome inhibitor MG-132 (1 h) and then incubated in DMSO w/w CPTH2 shows no significative changes...

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Hauptverfasser:	Cocco, Elisa, Leo, Manuela, Canzonetta, Claudia, Vito, Serena Di, Mai, Antonello, Rotili, Dante, Napoli, Arianna Di, Vecchione, Andrea, Nunzio, Cosimo De, Filetici, Patrizia, Stoppacciaro, Antonella
Format:	Bild
Sprache:	eng
Schlagworte:	Biochemistry Biotechnology Cancer Cell Biology Chemical Sciences not elsewhere classified Developmental Biology FOS: Biological sciences FOS: Chemical sciences FOS: Clinical medicine Genetics Hematology Immunology Microbiology Molecular Biology Neuroscience Pharmacology Physiology
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Zusammenfassung:	Immunostaining of K1 papyllary thyroid cells with p300 antibody after 72 h of treatment with CPTH2 (100 μM) compared to untreated and DMSO controls. Apoptotic percentage of 786-O cells treated with proteasome inhibitor MG-132 (1 h) and then incubated in DMSO w/w CPTH2 shows no significative changes of the apoptotic profiles compared to the untreated controls. p300 immunostaining of 786-O cells were pretreated for 1 h with proteasome inhibitor MG132, then grow in DMSO w/w CPTH2 for 18 h suggest that there is no significative proteolysis of p300 upon inhibition of the proteasome. (TIFF 30444 kb)
DOI:	10.6084/m9.figshare.6094199