Unsupervised cluster analysis of the combined gene expression data for 232 human breast tumor samples and 122 mouse mammary tumor samples

Copyright information:Taken from "Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors"http://genomebiology.com/2007/8/5/R76Genome Biology 2007;8(5):R76-R76.Published online 10 May 2007PMCID:PMC1929138. A color-coded matrix below the dendrogram identifies each sample; the first two rows show clinical ER and HER2 status, respectively, with red = positive, green = negative, and gray = not tested; the third row includes all human samples colored by intrinsic subtype as determined from Additional data file 6; red = basal-like, blue = luminal, pink = HER2+/ER-, yellow = claudin-low and green = normal breast-like. The remaining rows correspond to murine models indicated at the right. A gene cluster containing basal epithelial genes. A luminal epithelial gene cluster that includes and . A second luminal cluster containing 8 and 18. Proliferation gene cluster. Interferon-regulated genes. Fibroblast/mesenchymal enriched gene cluster. The amplicon cluster. See Additional data file 5 for the complete cluster diagram.