Editing by ADAR1, ADAR2 or dADAR generates the IIUI sequence

Copyright information:Taken from "Cleavage of dsRNAs hyper-edited by ADARs occurs at preferred editing sites"Nucleic Acids Research 2005;33(18):5954-5964.Published online 27 Oct 2005PMCID:PMC1270950.© The Author 2005. Published by Oxford University Press. All rights reserved () Sequence of ΔKP RNA (sense strand). An example of an adenosine triplet (A) is shown in bold. The cleavage site sequence (A) is underlined. () Efficiency of editing of ΔKP by ADAR2. Efficiency of editing is expressed as the percentage of clones that contain an inosine residue at each edited position. Hundred percent editing is indicated by a dotted line. Editing of the antisense and sense strands are shown at the top and bottom of the graph, respectively. Red bars show an example of editing of an adenosine triplet (A). () The average editing (%) of each adenosine preceded by a particular nucleotide (AX, CX, GX, UX) was calculated to give 5′ neighbor preferences. Similarly, the average editing (%) of each adenosine followed by a particular nucleotide (XA, XC, XG, XU) was calculated to give 3′ neighbor preferences. The total number of adenosines in each context is shown in brackets. () Efficiency of editing of ΔKP (antisense strand) by ADAR2, ADAR1 or dADAR. Efficiency of editing is expressed as the percentage of clones that contain an inosine residue at each edited position. Hundred percent editing is indicated by a dotted line. Blue bars indicate particular adenosine residues differentially edited by the three ADARs. The green bar indicates the adenosine residue within the cleavage site sequence.